Botox vs. Xeomin: Which Is Best for Me?

Botox, Xeomin, and Dysport are all used in cosmetic treatments to minimize signs of aging by smoothing out and relaxing wrinkles.

All three contain Botulism toxin type A and work similarly to each other. The main difference between Botox and Dysport is the dosage, while Xeomin contains less additives or complexing proteins. All three of these products are FDA-approved for the cosmetic treatment of wrinkles on the face. These are temporary treatment methods that generally last for a few months.

Botox is generally considered more effective on deeper wrinkles, while Xeomin may last a bit longer. Dysport can work on larger areas at a time. When choosing a wrinkle relaxer or cosmetic procedure, it is important to think about what you want to achieve. Cost should be considered as well. Botox is generally slightly more expensive, but it can take more units of Dysport at a time to achieve the same results.

Botox, Dysport, and Xeomin can all be effective cosmetic treatments. They are offered by Cosmetica in Boca Raton, Florida.


Wrinkle Relaxers

A wrinkle relaxer is an injection used for cosmetic purposes that relaxes the muscles that form fine lines, or wrinkles, on your face. Muscles contract in your face when you smile and frown, which can cause wrinkles to form around your eyes or on your forehead. Neuromodulators, such as Botulism toxin type A, can effectively relax and paralyze these muscles, smoothing the skin and reducing signs of aging. Botox, Dysport, and Xeomin are all neuromodulators that contain small doses of the Botulism toxin type A that can be injected into the skin to relax wrinkles. When carefully placed, the small doses can be an effective and safe method for anti-aging purposes.

Wrinkle relaxers are temporary. They will need to be readministered to maintain the desired look.

How Botox, Dysport & Xeomin Work

Botulism neurotoxins work by blocking nerve transmissions to the muscles around the eyes or on the forehead, which are what cause the appearance of wrinkles. Dysport, Botox, and Xeomin have similar mechanisms of action.

  • Botox (onabotulinumtoxinA) has been on the market the longest. It is FDA-approved to improve the look of crow’s feet around the eyes or frown lines (glabellar lines) between the eyebrows temporarily as a cosmetic injection. Botox also has several medical applications as well.

  • Dysport (abobotulinumtoxinA) is FDA-approved as an injectable for the temporary treatment of moderate to severe glabellar lines. It is also approved to treat cervical dystonia.

  • Xeomin (incobotulinumtoxinA) is the newest neuromodulator on the market. It is an injectable solution that is FDA-approved for a variety of medical reasons, as well as for the cosmetic purpose of temporarily improving the appearance of moderate to severe frown lines between the eyebrows.

Botox vs. Dysport

Botox and Dysport both use botulinum toxin and work the same way to smooth out wrinkles by paralyzing some of the facial muscles and blocking neurotransmitter transmissions. The biggest difference between these two types of wrinkle relaxers is their dosage.Botox and Xeomin contain the same amount of neurotoxin per dose, 150-kD. However, the Dysport dosage is about three times greater than the Botox or Xeomin dosage. This makes Dysport more potent, as one unit equals about three of the other two.

Xeomin vs. Botox & Dysport

Xeomin is considered a purer injectable, as it does not contain the same complexing protein that both Botox and Dysport do. There are fewer additives in Xeomin, which can mean there are fewer proteins interacting in the body. The molecular structure is slightly different even though the active ingredient is the same.Due to this, it can potentially work faster and have less potential for sensitivity and allergic reactions. There are also studies showing that Xeomin may be less effective and the dosage less predictable on deeper frown lines than Dysport, however.

Cost Comparison

On the surface, it can appear that Dysport is the least expensive neurotoxin wrinkle relaxer treatment. The difference is that you will need about double the amount of Dysport for the same results — for example, 40 units of Dysport versus 20 units of Botox. The cost of treatment will depend on the area treated and the number of units needed to achieve the desired result. Costs for Botox generally average around $550 per session, while Xeomin is about $425. Dysport generally costs around $450 per treatment session.

It is important to know that costs can vary widely from provider to provider and by location.

How Long Do Wrinkle Relaxers Last?

Botox, Dysport, and Xeomin are all temporary treatment methods that will need to be reused to continue smoothing out wrinkles. On average, Botox typically lasts between three and six months. It takes about seven to ten days after the treatment for the effects to be visible.According to the manufacturer, Dysport can last up to five months as a wrinkle relaxer, and it takes effect within two to three days. Since there is more active neurotoxin in a dose of Dysport, it can have a longer duration of action, working to keep wrinkles smooth for longer than Xeomin or Botox.Xeomin can last a few weeks longer than Botox, and it also begins to produce results a few days sooner. However, the two are mostly comparable in the amount of time they last.

Considerations When Choosing

All three of these muscle relaxers can have great results as anti-aging tools that help to smooth wrinkles and give you a younger-looking appearance. When deciding which is right for you, talk to your provider about what you want to achieve.

Here at Cosmetica in Boca Raton, we can help you to decide which one of these products best suits your needs.

  • For deeper frown lines, Botox is generally the optimal choice.
  • For a larger surface area, such as more of the forehead, Dysport can be a good option.
  • If you have a history of sensitivities to additives, Xeomin may be optimal.
  • If you want less frequent treatments, Dysport can help you achieve this.

Typically, people will respond better to or prefer one neurotoxin over another. It can take some trial and error to find the best fit for you.

When deciding between Botox, Dysport, and Xeomin in sunny South Florida, our professionals at Cosmetica can guide you. We’ll help you decide which option is best for you personally and ensure a smooth process from start to finish.


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Dysport for Injection. (April 2009). U.S. Food and Drug Administration (FDA).

Medication Guide Xeomin. (December 2020). U.S. Food and Drug Administration (FDA).

Conversion Ratio Between Botox, Dysport, and Xeomin in Clinical Practice. (March 2016). Toxins (Basil).

Patient-centric Dose Equivalency Pilot Study of Incobotulinumtoxin A (Xeomin) vs. Abotulinumtoxin A (Dysport) in the Treatment of Glabellar Frown Lines. (January 2015). Plastic and Aesthetic Research.

How Does Botulinum Toxin (Botox) Work? (March 2021). American Academy of Ophthalmology (AAO).

Dysport (AbotulinumtoxinA). (2021). Galderma Laboratories, L.P.

AbotulinumtoxinA (Dysport), OnobotulinumtoxinA (Botox), and IncobotulinumtoxinA (Xeomin) Neurotoxin Content and Potential Implications for Duration of Response in Patients. (December 2018). Toxins (Basil).

Botulinum Toxin in Aesthetic Medicine: Myths and Realities. (February 2018). Dermatologic Surgery.

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